Post-Doc Position – Directed Evolution of Carbene-Transferring Enzymes

In the group of Jun.-Prof. Martin Weissenborn applications for a Post-Doc position are invited. The Weissenborn lab is an independent junior research group at the Leibniz Institute of Plant Biochemistry (IPB) in Halle (Saale), Germany, a member of the Leibniz Association and foundation under public law, located on the Weinberg-Campus of the Martin Luther University (MLU) Halle-Wittenberg. The Weissenborn group is part of the Leibniz Research Cluster. 

The research will focus on performing directed evolution on enzymes catalysing carbene-transfer reactions. F.H. Arnold and R. Fasan have shown remarkable work on this and our lab found novel enzyme activities as well (see [1] Weissenborn, Löw et al. ChemCatChem 2016, 8, 1636-1640, [2] Weissenborn, Koenigs, et al. Iron-Catalyzed C-H Insertions 2018, ChemRxiv). The major focus is to establish directed evolution protocols in our lab and engineer proteins for the application in cell-free system. The cell-free system approach is followed in the Leibniz Research Cluster were we collaborate with groups from the polymer science, new materials and analytics to develop artificial cells. The focus of our research is to develop and provide highly interesting enzymes to be applied in these systems for the synthesis of natural products and pharmaceuticals.

What we offer: 

You will have the possibility to develop yourself in a young group with many new techniques and ideas in an inspiring research environment and outstanding equipment/facilities at the Leibniz-Institute. You will find flat hierarchies as well as close and regular interactions with the group leader. 

You will be encouraged to push yourself as well as the group to the next level, work on your own project as well as being heavily involved in finalising other group topics and techniques aiming for high impact. The group and the position is also part in the highly interdisciplinary Leibniz Research Cluster were we collaborate with Leibniz Institutes from Dresden, Jena, Saarbrücken and Dortmund including regular meetings and workshops. You will moreover benefit from courses and events offered at the Leibniz Institute and the neighbouring MLU.

Overall, you will develop into leading projects, co-supervising students, networking and visiting meetings/conferences. 

Location: 

Halle is a beautiful small city (240.000 inhabitants) one hour away from Berlin and 30 min from Leipzig. Due to the central location in Germany and excellent connection to the high-speed train network, you are very quickly in most areas of Germany (Frankfurt 3 hours, Hamburg 3.5 hours, Munich 3 hours) and due to the airport (Halle/Leipzig) in Europe.

Who should apply: 

The work in the Weissenborn-Group requires a high level of motivation. The PhD-thesis should be finalised and should have centred on metal-catalysis, directed evolution of enzymes or extended use of high throughput analysis by HPLC/GC. We have developed and established several techniques for high throughput screening starting from efficient cloning and mutagenesis techniques, versatile analytical tools, pipetting robots and automatic analysis using the programme R. As post-doc in the group, you should be able to learn and quickly apply these techniques as well as having a high interest to develop them further. 

How to apply:

For questions please contact martin.weissenborn(at)ipb-halle.de or any of the lab members (see www.ipb-halle.de ). If you are interested to work at the distinguished Leibniz-Institute then please apply until the 15th of June 2018. Applications must include a motivation letter, a CV with university transcripts (degrees and grades), and the names and addresses of two referees. Please email applications quoting reference number 9/2018 as a single pdf document to bewerbungen(at)ipb-halle.de.

The Weissenborn lab is an independent junior research group at the Leibniz Institute of Plant Biochemistry (IPB) in Halle (Saale), Germany, a member of the Leibniz Association and foundation under public law, located on the Weinberg-Campus of the Martin Luther University (MLU) Halle-Wittenberg. The Weissenborn group is part of the Leibniz Research Cluster.